p-Toluenesulfonic acid monohydrate → p-Toluenesulfonic acid

Participants

Reaction Steps

To m-phenoxybenzyl 2-(2-isoindolinyl)-3-methylbutanoate (492 mg, 1.23 mmol) is added a solution of para-toluenesulfonic acid monohydrate (249 mg, 1.31 mmol) in 4 ml of 95% ethanol. The reaction mixture is allowed to stand for 2 hours at RT under nitrogen. The ethanol is removed under vacuum and the residue recrystallized from 30% hexane/benzene to yield the para-toluenesulfonic acid salt of m-phenoxybenzyl 2-(2-isoindolinyl)-3-methylbutanoate, m.p. 139°-140.3°.

Provenance & Evidence