反应详情

A mixture of m-phenoxybenzyl 2-(4,5,6,7-tetrafluoro-2-isoindolinyl)-3-methylbutanoate (0.4 g), potassium hydroxide (0.134 g), ethanol (8 ml) and water (2 ml) is heated to reflux for 4 hours. After cooling, the reaction mixture is concentrated under vacuum and 50 ml of water is added. This mixture is washed with ether (3×). The aqueous phase is carefully adjusted to pH 7 and then extracted with ether (3×). The combined ether extracts are washed with water, dried and solvent removed under vacuum to yield 2-(4,5,6,7-tetrafluoro-2-isoindolinyl)-3-methylbutanoic acid, a white powder.

1. temperatureis heated
2. temperatureto reflux for 4 hours
3. temperatureAfter cooling
4. concentrationthe reaction mixture is concentrated under vacuum and 50 ml of water
5. additionis added
6. washThis mixture is washed with ether (3×)
7. extractionextracted with ether (3×)
8. washThe combined ether extracts are washed with water
9. customdried
10. customsolvent removed under vacuum