Ethanol → HCID 20382849, compound

Participants

Reaction Steps

A mixture of m-phenoxybenzyl 2-(4,7-difluoro-5,6-dichloro-2-isoindolinyl)-3-methylbutanoate (0.38 g), KOH (0.134 g), ethanol (8 ml) and water (2 ml) is heated to reflux for 14 hours. After cooling, the reaction is concentrated under vacuum and about 50 ml of water added. The mixture is washed with ether. The aqueous phase is adjusted to pH 7 and then the water is removed by evaporation to yield 2-(4,7-difluoro-5,6-dichloro-2-isoindolinyl)-3-methylbutanoic acid.

Provenance & Evidence