HCID 53792849, compound → HCID 54044274, compound

HRID 1447960Notes

Reaction equation

HRID 1447960 reaction equation
C([N:3]([CH:13]([CH3:15])[CH3:14])[C:4]([C:6]1[NH:7][C:8]([Cl:12])=[C:9]([Cl:11])[N:10]=1)=[O:5])=O>S(=O)(=O)(O)O>[CH:13]([NH:3][C:4]([C:6]1[NH:7][C:8]([Cl:12])=[C:9]([Cl:11])[N:10]=1)=[O:5])([CH3:15])[CH3:14]

Participants

3

Reactant 1

HCID 53792849HCID 53792849, compound

Product 1

HCID 54044274HCID 54044274, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

25 g (0.1 mol) of 4,5-dichloro-imidazole-2-carboxylic acid N-formyl-isopropylamide were stirred with 200 ml of concentrated sulphuric acid for about 15 minutes at 50°-70° C. After cooling, the mixture was poured onto ice and the product was filtered off, washed with water until neutral and dried. In this way, 16 g (72% of theory) of 4,5-dichloro-imidazole-2-carboxylic acid isopropylamide with a melting point of 150° C. were obtained.

Workup

  1. temperatureAfter cooling
  2. additionthe mixture was poured onto ice
  3. filtrationthe product was filtered off
  4. washwashed with water until neutral and
  5. customdried

Sources & evidence

ORD record
ord-24590ce6ad22449292fd4ba19e9e727a
Source dataset
uspto-grants-1979_12
Patent number
US04179277

Reaction notes

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