Ammonium Chloride → HCID 13952338, compound

Participants

Reaction Steps

3 g (15.8 mMole) of 4-benzoyl oxazolidin-2-one are dissolved in 100 ml of ethanol, followed by the addition in portions at room temperature of 900 mg (23.8 mMole) of sodium borohydride. The mixture is then stirred for 2.5 hours at room temperature. The reaction solution is then hydrolysed with a saturated ammonium chloride solution. The aqueous phase is repeatedly extracted with CHCl3, the organic phases are combined, dried over Na2SO4 and concentrated in a rotary evaporator. The oil is taken up in methanol. The crystals are filtered under suction.

Provenance & Evidence