Cyclohexyl bromide → HCID 20380992, compound

Participants

Reaction Steps

5.0 g (0.0262 mole) of 4-benzoyl oxazolidin-2-one dissolved in 100 ml of absolute tetrahydrofuran are added dropwise while cooling with ice to a Grignard solution prepared from 12.8 ml (0.127 mole) of bromocyclohexane and 2.98 g (0.128 gram equivalent) of magnesium in 150 ml of absolute tetrahydrofuran. This solution is stirred for 2 hours at 60° C., subsequently hydrolysed with approximately 500 ml of a saturated ammonium chloride solution and repeatedly extracted with chloroform. The organic phases are combined, dried over Na2SO4 and concentrated in a rotary evaporator. The oil is taken up in ether. The crystals formed are filtered off under suction.

Provenance & Evidence