Sodium Hydroxide → HCID 20301069, compound

HRID 1448035Notes

Reaction equation

HRID 1448035 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]1[CH:12]=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][N:6]1[C:5]2=[O:19].[OH-:20].[Na+]>O>[C:5]([C:4]1[CH:3]=[C:2]([CH3:1])[CH:11]=[CH:10][C:9]=1[NH:8][C:7]1[CH:12]=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][N:6]=1)([OH:19])=[O:20]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 304724611H-Pyrido(2,1-b)quinazoline-8-carboxylic acid, 2-methyl-11-oxo-

Product 1

HCID 20301069HCID 20301069, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 10.0 g (39.4 mmol) of 2-methyl-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid and 78.8 ml of 1 N. NaOH in 500 ml of H2O was heated at reflux for 16 hours. The reaction mixture was evaporated to give a white powder which was triturated with hot EtOH giving the analytical sample upon filtration and drying; yield, 8.25 g (66.5%) mp 348.5° dec.

Workup

  1. temperatureat reflux for 16 hours
  2. customThe reaction mixture was evaporated
  3. customto give a white powder which
  4. customwas triturated with hot EtOH giving the analytical sample
  5. filtrationupon filtration
  6. customdrying
  7. customyield

Sources & evidence

ORD record
ord-a027283e5ab648a18a2611ecd81edec5
Source dataset
uspto-grants-1979_12
Patent number
US04179509

Reaction notes

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