2-Propanethiol → HCID 53734952, compound

HRID 1448041Notes

Reaction equation

HRID 1448041 reaction equation
[CH:1]([SH:4])([CH3:3])[CH3:2].C[O-].[Na+].[CH3:8][C:9]1([CH3:23])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12](=[O:19])[N:11]([CH2:20]Cl)[C:10]1=[O:22]>CO>[CH3:8][C:9]1([CH3:23])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12](=[O:19])[N:11]([CH2:20][S:4][CH:1]([CH3:3])[CH3:2])[C:10]1=[O:22]

Participants

5

Reactant 3

HCID 63642-PropanethiolHCID 10942334Sodium MethoxideHCID 20381220HCID 20381220, compound

Product 1

HCID 53734952HCID 53734952, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.17 gm of isopropylmercaptan were added to a solution of 0.83 gm of sodium methylate in 50 ml of methanol. After shaking the resulting mixture, 3.3 gm of 4,4-dimethyl-2-chloromethyl-2H,4H-isoquinoline-1,3-dione were added, and the mixture was refluxed for 15 minutes. The precipitated sodium chloride was suction-filtered off, the filtrate was evaporated, and the residue was purified on a silicagel column (eluant: chloroform/cyclohexane=1:1). After evaporation of the eluate a colorless oil was obtained.

Workup

  1. additionwere added
  2. temperaturethe mixture was refluxed for 15 minutes
  3. filtrationThe precipitated sodium chloride was suction-filtered off
  4. customthe filtrate was evaporated
  5. customthe residue was purified on a silicagel column (eluant: chloroform/cyclohexane=1:1)
  6. customAfter evaporation of the eluate a colorless oil
  7. customwas obtained

Sources & evidence

ORD record
ord-739f151fffa446dab835b49445fc5c4e
Source dataset
uspto-grants-1979_12
Patent number
US04179508

Reaction notes

Loading…