反应详情

To a solution of 2-(4-chlorophenyl)-4-chlorosulfonylimidazole (1.3 g 0.005 m) in dioxane (15 ml) was added ethanolamine (0.61 g 0.01 ml). After 15 minutes the dioxane was removed under reduced pressure (20 mm) to yield a gum. The gum was slurried with water to yield a solid. The solid was filtered and recrystallized from acetonitrile to give 400 mg of 2-(4-chlorophenyl)-4-(2-hydroxyethylsulfamoyl)imidazolemelting at 210°-212°. (20% yield).

1. customAfter 15 minutes the dioxane was removed under reduced pressure (20 mm)
2. customto yield a gum
3. customto yield a solid
4. filtrationThe solid was filtered
5. customrecrystallized from acetonitrile
6. customto give 400 mg of 2-(4-chlorophenyl)-4-(2-hydroxyethylsulfamoyl)imidazolemelting at 210°-212°