Water → HCID 20381756, compound

Participants

Reaction Steps

6.73 g (0.16 mole) of 57% sodium hydride in mineral oil was washed with hexane and suspended in 500 ml of THF. To this was added 43.4 g (0.139 mole) of methyl-3-[o-nitrophenoxy]-indole-2-carboxylate. The mixture was stirred at reflux for 1 hour, then 42.6 g (0.3 mole) of methyl iodide was added and reflux continued for 3 hours. Water (5 ml) was added, the THF removed by distillation and the gummy residue recrystallized from isopropanol to give analytical material as yellow needles, mp. 119°-21°.

Provenance & Evidence