Piperazine → HCID 70607392, compound

Participants

Reaction Steps

To a solution of 13 g of 4-chloro-3-phenoxypyridine in 25 ml of methanol is added 30 g of piperazine and the solution is stirred and heated for 72 hours. The resulting mixture is concentrated at reduced pressure. The residue is shaken with 500 ml of ether and excess dilute aqueous sodium hydroxide. The organic phase is separated, dried and filtered. The filtrate is concentrated and the product distilled to give 3-phenoxy-4-piperazinylpyridine; bp 134°-135° C./0.2 mm, solidified and has a mp of 74°-77° C.

Provenance & Evidence