Bromine → HCID 70608027, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 81.5 g of 2-piperazinylpyridine [J. Org. Chem., 18, 1484 (1953)] in 250 g of 48% hydrobromic acid is heated at 70° C. With stirring, 80 g of liquid bromine is added dropwise. The mixture is heated at 115° C. for 1 hour. The mixture is cooled and the product 3-bromo-6-piperazinylpyridine hydrobromide is isolated by filtration. The salt is treated with excess dilute sodium hydroxide and extracted into toluene. The 3-bromo-6-piperazinylpyridine crystallizes as the solvent is removed in vacuo and is recrystallized from toluene-petroleum ether; mp 70°-73° C.

Provenance & Evidence