Formic Acid → HCID 135737574, compound

HRID 1448173Notes

Reaction equation

HRID 1448173 reaction equation
[OH:1][CH2:2][C:3]1[CH:15]=[C:14]2[N:5]([C:6](=[O:16])[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=32)[N:4]=1.[CH:17](O)=[O:18]>>[CH:17]([O:1][CH2:2][C:3]1[CH:15]=[C:14]2[N:5]([C:6](=[O:16])[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=32)[N:4]=1)=[O:18]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 135449340Pirquinozol

Product 1

HCID 135737574HCID 135737574, compoundYield 75%

Procedure

2-(Hydroxymethyl)pyrazolo[1,5-c]quinazolin-5(6H)-one (3.3 g, 0.0153 mole) is suspended in 250 ml of 97-100% formic acid and refluxed overnight under nitrogen. The solution is stripped to dryness and the solid is recrystallized from dioxane to give 2.8 g (75% yield) of analytically pure title compound, m.p. 190°-192°.

Workup

  1. temperaturerefluxed overnight under nitrogen
  2. customthe solid is recrystallized from dioxane

Sources & evidence

ORD record
ord-2eb2685b3eb248f0ae5752142d9758e8
Source dataset
uspto-grants-1979_12
Patent number
US04179561

Reaction notes

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