HCID 136463927, compound → HCID 136425302, compound

HRID 1448183Notes

Reaction equation

HRID 1448183 reaction equation
C([O:3][C:4]([C:6]1[C:18]([CH3:19])=[C:17]2[N:8]([C:9](=[O:20])[NH:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=32)[N:7]=1)=[O:5])C>[OH-].[K+]>[CH3:19][C:18]1[C:6]([C:4]([OH:5])=[O:3])=[N:7][N:8]2[C:17]=1[C:16]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH:10][C:9]2=[O:20]

Participants

3

Reactant 1

HCID 136463927HCID 136463927, compound

Product 1

HCID 136425302HCID 136425302, compound

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

A suspension of 25.7 g (0.10 mole) of 1-methyl-pyrazolo[1,5-c]quinazolin-5(6H)-one-2-carboxylic acid ethyl ester in 2.5 l of 10% alcoholic potassium hydroxide is refluxed for 3 hours, cooled to room temperature and filtered. The solid is dissolved in water extracted with chloroform, treated with Norit-A and filtered. The filtrate is cooled in an ice bath and acidified (Congo red) with 25 ml of concentrated hydrochloric acid. The white precipitate is filtered, digested with 1 l. of hot water and filtered, and dried to give the title compound.

Workup

  1. temperatureis refluxed for 3 hours
  2. filtrationfiltered
  3. dissolutionThe solid is dissolved in water
  4. extractionextracted with chloroform
  5. additiontreated with Norit-A
  6. filtrationfiltered
  7. temperatureThe filtrate is cooled in an ice bath
  8. filtrationThe white precipitate is filtered
  9. filtrationof hot water and filtered
  10. customdried

Sources & evidence

ORD record
ord-b4e2fedf4b424400a072ca58dc988964
Source dataset
uspto-grants-1979_12
Patent number
US04179561

Reaction notes

Loading…