Phosgene → HCID 12298225, compound

HRID 1448293Notes

Reaction equation

HRID 1448293 reaction equation
[C:1](Cl)(Cl)=[O:2].[NH:5]([C:12]1([C:23]([OH:25])=[O:24])[CH2:17][CH2:16][N:15]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>O1CCOCC1>[O:2]=[C:1]1[O:24][C:23](=[O:25])[C:12]2([CH2:13][CH2:14][N:15]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:16][CH2:17]2)[N:5]1[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 6371Phosgene2×HCID 12298145HCID 12298145, compound

Product 1

HCID 12298225HCID 12298225, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Phosgene gas is introduced through a stirring mixture of 29.2 parts of 4-anilino-1-(ethoxycarbonyl)isonipecotic acid in 240 parts of dioxane: exothermic reaction (temperature rises to 45° C.). Stirring is continued for 30 minutes at 45° C. The mixture is heated to reflux and phosgene gas is gently introduced for 2 h. 30. Then nitrogen gas is introduced for 30 minutes. The reaction mixture is evaporated in a boiling water-bath for 30 minutes. The solid residue is triturated in ether, yielding ethyl 2,4-dioxo-1-phenyl-3-oxa-1,8-diazaspiro[4,5]decane-8-carboxylate; mp. 210.7° C.

Workup

  1. customexothermic reaction (temperature rises to 45° C.)
  2. temperatureThe mixture is heated
  3. temperatureto reflux
  4. additionThen nitrogen gas is introduced for 30 minutes
  5. customThe reaction mixture is evaporated in a boiling water-bath for 30 minutes
  6. customThe solid residue is triturated in ether

Sources & evidence

ORD record
ord-dbd75f29aa0c4aedb1a1353a6e620f35
Source dataset
uspto-grants-1979_12
Patent number
US04179569

Reaction notes

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