Sodium Carbonate → 2-(6-Carboxy-2-cis-hexenyl)cyclopent-2-en-1-one

Participants

Reaction Steps

A solution of 3 g. of crude 2-(6-carboxy-2-cis-hexenyl)cyclopent-3-en-1-one (Example 56) in 100 ml. of aqueous sodium carbonate (pH: 10-11) is stirred at ambient temperature under nitrogen for 4 hours. The solution is acidified to Congo Red and extracted into ether. The ethereal extracts are dried over sodium sulfate and evaporated at reduced pressure to afford the product. See also P. A. Grieco and J. J. Reap, J. Org. Chem., 38, 3413 (1973).

Provenance & Evidence