Phenol → HCID 54239202, compound

Participants

Reaction Conditions

Reaction Steps

A solution of phenol (2.3 g, 0.025 mole) and triethylamine (3.49 ml, 0.025 mole) in 50 ml. of ether was added to a solution of ethyl N-trifluoroacetyl-N-(dichlorophosphonomethyl)glycinate (8.25 g, 0.025 mole) in 150 ml. of ether at 0° C. After two hours, the solution was filtered and the filtrate was added to a cooled (0° C.) solution of N-aminopiperidine (5.2 ml, 0.05 mole) in 100 ml. of ether. The resulting solution was stirred at 25° C. for 16 hours, then filtered. The filtrate was washed with 0.3% hydrochloric acid, dried over sodium sulfate and concentrated in vacuo to afford ethyl N-trifluoroacetyl-N-(phenoxy(N-piperidinoamino)phosphonomethyl)glycinate which could not be further purified by any means.

Provenance & Evidence