Thiophenol → HCID 54085838, compound

Participants

Reaction Steps

A solution of diethylamine (5.0 ml, 0.05 mole) in 50 ml. of ether was added to a solution of ethyl N-trifluoroacetyl-N-(dichlorophosphonomethyl)glycinate (8.25 g, 0.025 mole) in 150 ml. of ether at 0° C. The solution was stirred for two hours, then filtered and the filtrate treated with a solution of thiophenol (2.4 ml, 0.025 mole) and triethylamine (3.4 ml, 0.025 mole) in 50 ml. of ether at 0° C. After stirring overnight, the solution was filtered and the filtrate was washed with 0.3% aqueous hydrochloric acid, dried over sodium sulfate and concentrated in vacuo to yield ethyl N-trifluoroacetyl-N-(diethylamino(phenylthio)phosphonomethyl)glycinate (8.7 g) as a yellow oil, ND22 =1.5049.

Provenance & Evidence