2-Nitro-4-(trifluoromethyl)phenol → 2-Amino-4-(trifluoromethyl)phenol

HRID 1448471Notes

Reaction equation

HRID 1448471 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[OH:14])([O-])=O>C(O)C.[Pt]=O>[NH2:1][C:4]1[CH:9]=[C:8]([C:10]([F:11])([F:12])[F:13])[CH:7]=[CH:6][C:5]=1[OH:14]

Participants

4

Reactant 1

HCID 98162-Nitro-4-(trifluoromethyl)phenol

Product 1

HCID 1202462-Amino-4-(trifluoromethyl)phenol

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

82.2 g of 7A was dissolved in 300 ml of ethanol. 0.5 g of platinum oxide catalyst was added and the mixture was hydrogenated at 50 p.s.i.g. Fresh portions of catalyst were added periodically. The resulting mixture was filtered, and the solvent was evaporated from the filtrate. The residue was crystallized from water to give 2-amino-4-trifluoromethyl-phenol (7B).

Workup

  1. additionFresh portions of catalyst were added periodically
  2. filtrationThe resulting mixture was filtered
  3. customthe solvent was evaporated from the filtrate
  4. customThe residue was crystallized from water

Sources & evidence

ORD record
ord-0926e4256e6e4739bad1bd531d29f63a
Source dataset
uspto-grants-1979_12
Patent number
US04180572

Reaction notes

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