Hydrochloric Acid → Phenol, 4-methoxy-2-nitro-

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Reaction Steps

336.4 g of 2-nitro-4-methoxyaniline was refluxed for 20 hours with 200 g of sodium hydroxide and 10 g of arsenic trioxide, in 6500 ml of water. The resulting solution was cooled on an ice-bath, then acidified to pH 1 with concentrated hydrochloric acid. The solid which formed was filtered and washed with water and dried under reduced pressure over P2O5 to give 2-nitro-4-methoxyphenol, 8A, m.p.: 78°-80°.

Provenance & Evidence