1-Chloro-4-(chloromethyl)benzene → HCID 20379913, compound

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Reaction Steps

A mixture of 6.44 g. of 4-chlorobenzyl chloride, 4.97 g. of N-propynyl piperazine, 8.48 g. of sodium carbonate and 50 ml. of ethanol was refluxed for 18 hours. The mixture was then filtered and the filtrate evaporated in vacuo. The residual oil was dissolved in chloroform which solution was washed with water and then dried over magnesium sulfate. The mixture was then filtered and the filtrate was evaporated under vacuum and subsequently distilled to give a yellow oil of the expected N'-(4-chlorobenzyl)-N-propynyl piperazine, b.p. 162°-5° C./1.5 mm, which produces a single spot of T.L.C. and the expected NMR and IR spectra.

Provenance & Evidence