HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 70606673, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | alpha-(p-Fluorophenyl)-4-(alpha-hydroxy-alpha-phenylbenzyl)-1-piperidinebutanol | HCID 19937439 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 70606673 | HCID 70606673 | — |
Reaction Steps
A mixture of 15 g (0.034 mole) of α-(p-fluorophenyl)-4-(α-hydroxy-α-phenylbenzyl)-1-piperidinebutanol, 400 ml of concentrated HCl and 1500 ml of isopropyl alcohol was heated on a steam bath for 16 hours. The isopropyl alcohol was then concentrated by heating, and the remaining solution was cooled to room temperature. A precipitate formed which was collected on a filter and recrystallized from isopropyl alcohol and ethyl acetate to give the desired product, M.P. 166°-168.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04180583 |
| Source dataset | uspto-grants-1979_12 |
| ORD ID | ord-4d523d09a7b74ee4ae3862c7dd5d443a |
| Source note | uspto-grants-1979_12 |