Hydrochloric Acid → HCID 70607076, compound

Participants

Reaction Steps

A mixture of 63.4 g (0.134 mole) of α-(p-tert-butylphenyl)-4-(α-hydroxy-α-phenylbenzyl)-1-piperidinebutanol hydrochloride, 400 ml of 37% HCl, and 250 ml of butanone was refluxed under a nitrogen atmosphene for 17 hours. The solvent and excess acid were removed under vacuum. The mixture was extracted into toluene, and a precipitate formed upon addition of ether. After cooling, the precipitate was collected by filtration, washed with ether and recrystallized from ethyl acetate to give the desired product, M.P. 224°-231° C.

Provenance & Evidence