Hydrochloric Acid → HCID 70607438, compound

Participants

Reaction Steps

A mixture of 10 g (0.02 mole) of α-(p-bromophenyl)-4-(α-hydroxy-α-phenylbenzyl)-1-piperidinebutanol, 150 ml of conentrated HCl, 150 ml of water and 50 ml of n-butanol was heated for 2 hours at reflux. The solvent was removed under vacuum, and the remaining residue was recrystallized from ethyl acetate to give the desired product, M.P. 215°-217° C. Alternatively, the title compound may be prepared by a similar acid dehydration reaction of α-(p-bromophenyl)-4-(diphenylmethylene)-1-(piperidinebutanol hydrochloride, M.P. 215°-217° C.

Provenance & Evidence