1-Butanone, 1-(4-fluorophenyl)-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-, hydrochloride → HCID 20379997, compound

HRID 1448502Notes

Reaction equation

HRID 1448502 reaction equation
[ClH:1].FC1C=CC(C(=O)CCCN2CCC(C(O)(C3C=CC=CC=3)C3C=CC=CC=3)CC2)=CC=1.Cl.O[C:36]([CH:49]1[CH2:54][CH2:53][N:52]([CH2:55][CH2:56][CH2:57][C:58]([C:60]2[CH:65]=[CH:64][C:63]([O:66][CH3:67])=[CH:62][CH:61]=2)=[O:59])[CH2:51][CH2:50]1)([C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1)[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1>>[ClH:1].[C:43]1([C:36]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[C:49]2[CH2:50][CH2:51][N:52]([CH2:55][CH2:56][CH2:57][C:58]([C:60]3[CH:61]=[CH:62][C:63]([O:66][CH3:67])=[CH:64][CH:65]=3)=[O:59])[CH2:53][CH2:54]2)[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=1

Participants

3

Reactant 2

HCID 2061821-Butanone, 1-(4-fluorophenyl)-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-, hydrochlorideHCID 20380016HCID 20380016, compound

Product 1

HCID 20379997HCID 20379997, compound

Procedure

By the procedure of Example 3 only substituting for 4'-fluoro-4-[4-(α-hydroxy-α-phenylbenzyl)piperidino]butyrophenone hydrochloride an appropriate amount of 4-[4-(α-hydroxy-α-phenylbenzyl)piperidino]-4'-methoxybutyrophenone hydrochloride, the desired product was obtained upon recrystallization from methanol-benzene, M.P. 185.5°-187° C.

Sources & evidence

ORD record
ord-2dcf353a65814b008306f9498d210df6
Source dataset
uspto-grants-1979_12
Patent number
US04180583

Reaction notes

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