Sodium Nitrite → HCID 54569597, compound

1-(β-D-mannopyranosyl)-3-methyl-urea (200 mg) was dissolved in a mixture of 1.5 ml of glacial acetic acid and 3.5 ml of water, and the resulting solution was admixed with 99 mg of sodium nitrite. The mixture so obtained was agitated for 3 hours at ambient temperature to effect the nitrosation. The reaction mixture was treated with Amberlite IR-120 (H+ form) to remove sodium cation therefrom. The reaction mixture so treated was then concentrated by distillation under reduced pressure at a temperature of less than 30° C. to remove the solvent, so that a crystalline product was deposited. This crystalline product was collected by filtration and washed with n-propanol, affording 180 mg of the titled compound. Yield 78%. mp. 103° C. (with decomposition). [α]D25 -12.6° (c 0.99, H2O).

1. customThe mixture so obtained
2. additionThe reaction mixture was treated with Amberlite IR-120 (H+ form)
3. customto remove sodium cation
4. additionThe reaction mixture so treated
5. concentrationwas then concentrated by distillation under reduced pressure at a temperature of less than 30° C.
6. customto remove the solvent
7. filtrationThis crystalline product was collected by filtration
8. washwashed with n-propanol

ORD record

ord-f3e49bf52f4e4892ab636ca212337f2a

Source dataset

uspto-grants-1979_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04180655