Methyl iodide → HCID 12669659, compound

Participants

Reaction Steps

A mixture of 25 parts of 3,9-dihydro-3,9-dioxo-1-phenyl-2H-indeno[2,1-c]pyridine-4-carbonitrile, 114 parts of iodomethane, 115 parts of potassium carbonate, and 475 parts of N,N-dimethylformamide is heated at 85° for 11/4 hours, then diluted with 1500 parts of water, followed by 100 parts of aqueous 5% sodium hydroxide. The deep tan precipitate which forms is filtered off, dried in air, and consecutively recrystallized from a mixture of chloroform and hexane, ethyl acetate, a mixture of ethyl acetate and chloroform, and acetonitrile to give 3,9-dihydro-2-methyl-3,9-dioxo-1-phenyl-2H-indeno-[2,1-c]pyridine-4-carbonitrile melting at approximately 255°-256°. The product has the formula ##STR15##

Provenance & Evidence