2-Aminopyridine → HCID 54717105, compound

Participants

Reaction Steps

3.54 g. of 6-bromo-4-hydroxy-2-methyl-3-methoxycarbonyl-2H-thieno[2,3-e]-1,2-thiazine-1,1-dioxide are boiled under reflux for 6 hours with 1.42 g. of 2-aminopyridine in 150 ml. of absolute xylene. The reaction mixture is allowed to cool to room temperature. The precipitated crude product is recrystallized from dioxane and 6-bromo-4-hydroxy-2-methyl-3-(2-pyridylcarbamyol)-2H-thieno[2,3-e]-1,2-thiazine-1,1-dioxide having a melting point of 232°-235° is obtained.

Provenance & Evidence