4-Aminopyridine → HCID 20380322, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 11.4 grams (0.05 mole) of benzilic acid and 4.7 grams (0.05 mole) of 4-aminopyridine was heated at 220° C. for 3.5 hours. After cooling the mixture was dissolved in toluene and washed with 10% sodium carbonate solution and with 2 N hydrochloric acid. The acidic extracts were basified with 5 N sodium hydroxide and the resulting oil extracted into toluene. After drying over magnesium sulphate, the toluene was removed and the yellow oil was recrystallised from light petroleum (b.p. 80°-100° C.) giving 1.35 grams (10% yield) of the title compound, m.p. 152° to 154° C.

Provenance & Evidence