Formaldehyde → HCID 53742100, compound

Participants

Reaction Steps

44.6 g (0.2 mol) of 4,5-dichloro-imidazole-2-carboxylic acid isopropyl ester were stirred in 200 ml of acetonitrile together with 12 g (0.4 mol) of paraformaldehyde, 40.7 g (0.4 mol) of acetic anhydride and 0.5 g of p-toluenesulphonic acid for 20 hours at 85° C. After distilling off the solvent and stirring the residue in isopropanol, 38 g (64% of theory) of 1-acetoxymethyl-4,5-dichloro-imidazole-2-carboxylic acid isopropyl ester with a melting point of 81°-82° C. were obtained.

Provenance & Evidence