Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1448682Generated: October 31, 2026

Sodium Hydroxide → 3-(m-Tolyl)-4,5-Isothiazoledicarboxylic Acid

https://huagongshe.com/reaction/1448682

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
ReactantDimethyl 3-(m-Tolyl)-4,5-IsothiazoledicarboxylateHCID 12437411—
SolventWaterHCID 962—
Product3-(m-Tolyl)-4,5-Isothiazoledicarboxylic AcidHCID 12437431—

Reaction Steps

Dimethyl 3-(m-tolyl)-4,5-isothiazoledicarboxylate (14.03 g, 0.0548 mol) was hydrolyzed in NaOH (10.96 g, 0.274 mol) and 50 ml H2O for 0.5 hours at reflux. Acidification with HCl, extraction with ether and recrystallization gave a light yellow solid, m.p. 166.5°-167° with decomposition.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04187099
Source datasetuspto-grants-1980_02
ORD IDord-3f25c2689c9d4204a2c1f0ee57157080
Source noteuspto-grants-1980_02