Boron trifluoride etherate → HCID 12437468, compound

Participants

Reaction Steps

3-(p-Tolyl)-4-isothiazolecarboxylic acid (1.5 g, 0.0068 mol), 20 ml of absolute ethanol, and boron trifluoride etherate (4.3 ml, 0.034 mol) were heated at reflux for 24 hours. Volatile materials were removed under reduced pressure. Water (25 ml) was added and the material extracted four times with ether. The ether was back-extracted with 5% NaHCO3, dried (CaSO4) and concentrated under reduced pressure to yield 1.51 g (0.0061 mol, 89.9%) of oil, nD25 =1.5671.

Provenance & Evidence