HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Iodohexane → N-n-Hexyl-N-(3-carbethoxy-5-ethyl-2-thienyl)-2-methylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Iodohexane | HCID 12527 | — |
| Reactant | Ethyl 2-amino-5-ethyl-3-thenoate | HCID 78263 | — |
| Reactant | Ethyl 5-ethyl-2-(2-methylpropanoylamino)thiophene-3-carboxylate | HCID 734585 | — |
| Product | N-n-Hexyl-N-(3-carbethoxy-5-ethyl-2-thienyl)-2-methylpropanamide | HCID 53840912 | — |
Reaction Steps
Ethyl 2-amino-5-ethyl-3-thiophenecarboxylate (Chemische Berichte 99, 94 (1966)) was converted into N-(3-carbethoxy-5-ethyl-2-thienyl)-2-methylpropanamide by the method described in Example 41. Alkylation of the unpurified product with n-hexyl iodide as described in Example 43 gave the title compound as a light yellow oil, b.p. 145°-147° C./0.25 mm. NMR showed that the material was the correct product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04187232 |
| Source dataset | uspto-grants-1980_02 |
| ORD ID | ord-72e781b7b3d6469792c36ecc502eac00 |
| Source note | uspto-grants-1980_02 |