Sulfuric Acid → HCID 20375429, compound

Participants

Reaction Steps

160 g of 73% strength aqueous sulphuric acid are added dropwise to a mixture of 54.5 g of 1,2-di-(4-methoxyphenyl)-2-oxo-ethanol (p-anisoin) and 73 g of 3,4-dimethylphenol and the mixture is heated at 130°-135° for 20 minutes and then cooled to 20°. The reaction mixture is rendered alkaline by adding an aqueous solution of sodium hydroxide and is heated under reflux and then cooled. It is extracted twice with ethyl acetate; the combined organic extracts are washed with a 2 N aqueous solution of sodium hydroxide and with water, dried over sodium sulphate and filtered and the filtrate is concentrated to half its volume and cooled. The crystalline precipitate is filtered off and recrystallised from ethyl acetate and gives 2,3-di-(4-methoxyphenyl)-5,6-dimethylbenzofurane, melting point 153°.

Provenance & Evidence