2,4-Dichloro-5-fluoropyrimidine → 2-chloro-N4-(3-chloro-4-trifluoromethoxyphenyl)-5-fluoro-4-pyrimidineamine

HRID 144872Notes

Reaction equation

HRID 144872 reaction equation
[Cl:10][c:11]1[cH:12][c:13]([NH2:14])[cH:15][cH:16][c:17]1[O:18][C:19]([F:20])([F:21])[F:22].[Cl:1][c:2]1[n:3][cH:4][c:5]([F:9])[c:6]([Cl:8])[n:7]1>>[Cl:1][c:2]1[n:3][cH:4][c:5]([F:9])[c:6]([NH:14][c:13]2[cH:12][c:11]([Cl:10])[c:17]([O:18][C:19]([F:20])([F:21])[F:22])[cH:16][cH:15]2)[n:7]1

Participants

3

Reactant 2

HCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 27738433-Chloro-4-(trifluoromethoxy)aniline

Product 1

HCID 220604622-chloro-N4-(3-chloro-4-trifluoromethoxyphenyl)-5-fluoro-4-pyrimidineamine

Sources & evidence

ORD record
ord-6ca002392a484684b7f6cf25038c3bb7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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