Hydrochloric Acid → HCID 131711714, compound

Participants

Reaction Steps

2.9 ml of 5.6 N HCl in dioxan and 0.67 ml of tert. butyl nitrite are added at -20° to a solution of 3.2 g of Z-Trp-Ala-Ser-Gly-NHNH2 in 50 ml of DMF. After standing 15 minutes at -20° 1.89 of L-Asparaginol hydrochloric and 2.5 ml of triethylamine are added. After standing for 15 hours at room temperature the reaction mixture is considerably reduced in volume, diluted with ethyl acetate and washed with dilute aqueous hydrochloride acid and with water. The title compound precipitates from the concentrated solution.

Provenance & Evidence