Ammonia → Cyromazine

HRID 1448779Notes

Reaction equation

HRID 1448779 reaction equation
[CH:1]1([NH:4][C:5]2[N:10]=[C:9]([NH2:11])[N:8]=[C:7](Cl)[N:6]=2)[CH2:3][CH2:2]1.[NH3:13]>O1CCOCC1>[CH:1]1([NH:4][C:5]2[N:10]=[C:9]([NH2:11])[N:8]=[C:7]([NH2:13])[N:6]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 233389806-Chloro-N~2~-cyclopropyl-1,3,5-triazine-2,4-diamine

Product 1

HCID 47866Cyromazine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
140 °C

Procedure

A mixture of 100 g of 2-cyclopropylamino-4-amino-6-chloro-s-triazine, 51 g of ammonia and 500 ml of dioxan is heated at 140° C. in an autoclave for 24 hours. After cooling, the dioxan is removed by filtering with suction in vacuo and the crystalline residue is washed with water and dried. The crude product is recrystallised from methanol; melting point 219°-222° C.

Workup

  1. temperatureAfter cooling
  2. customthe dioxan is removed
  3. filtrationby filtering with suction in vacuo
  4. washthe crystalline residue is washed with water
  5. customdried
  6. customThe crude product is recrystallised from methanol

Sources & evidence

ORD record
ord-6df5ee0c59d94fae9fed6e8532cbaf30
Source dataset
uspto-grants-1980_02
Patent number
US04187304

Reaction notes

Loading…