Hydrochloric Acid → HCID 70594093, compound

Participants

Reaction Steps

7.9 g (32.7 mmol) of 3-chloromethyl-2-N-methylthiophenesulfonamide and 4.7 g (72 mmol) of potassium cyanide are heated to 80° C. for 15 minutes in 40 ml of triethyleneglycol. Thereafter, the mixture is poured into 100 ml of 2-N hydrochloric acid and 50 g of ice and extracted with three 200 ml portions of methylene chloride. The combined organic phases are dried over sodium sulfate, stirred with 1 g of active carbon, filtered and evaporated to give a noncrystallizing oil. There is obtained 3-cyanomethyl-2-N-methylthiophenesulfonamide.

Provenance & Evidence