反应详情

To a solution of 17.1 g of 3-phenoxypyridine [J. Amer. Chem. Soc 59, 297 (1937)] in 100 ml of acetonitrile is added 16.7 g of ethyl bromoacetate and the solution is refluxed for 8 hours. The resulting mixture is concentrated at reduced pressure and the crystalline solid is isolated by filtration to yield 1-(2-ethoxy-2-oxoethyl)-3-phenoxypyridinium bromide; mp 125°-126° C. after recrystallization from acetonitrile-diethyl ether.

1. temperaturethe solution is refluxed for 8 hours
2. concentrationThe resulting mixture is concentrated at reduced pressure
3. customthe crystalline solid is isolated by filtration