Trifluoroacetic acid → HCID 20375745, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 16.5 g of methyl 3-(p-methoxybenzyloxycarbonylamino)-1,5-cyclohexadienecarboxylate in 40 ml of anisole at about 25° C. is added slowly 30 ml of trifluoroacetic acid. After the addition of the first 5 ml the solid dissolves. The solution is cooled in a ice bath and the addition of trifluoroacetic acid continues. The solution is maintained at 0° C. for one hour, then the solvents are removed in vacuo (1 mm) maintaining the temperature below 40° C. The resulting oily residue is cooled to 0° C. and anhydrous ether added with stirring. The precipitate is filtered off to give 8.1 g of methyl 3-amino-1,5-cyclohexadienecarboxylate trifluoroacetate.

Provenance & Evidence