Methyl chloroformate → HCID 20375741, compound

Participants

Reaction Steps

A solution of 240 mg (1 m mole) of 3-tert-butoxycarbonylamino-1,5-cyclohexadiene carboxylic acid in 5 ml of dichloromethane is treated with 202 mg (2 m mole) of triethylamine and 94 mg (1 m mole) of methyl chloroformate. After 30 minutes at 25° C. the solution is treated with 60 mg (1 m mole) of n-propylamine for 1 hour at 25° C. after which the solution is diluted with dichloromethane, washed with water, dryed and evaporated. The residue is stirred for 18 hours in 7 ml of methanol and 3.5 ml of 5% aqueous HCl. Evaporation affords N-propyl-3-amino-1,5-cyclohexadienecarboxamide hydrochloride.

Provenance & Evidence