Hydrochloric Acid → HCID 12802755, compound

Participants

Reaction Steps

A solution of diethyl α-(1-benzyl-1,2-dihydro-2-oxoquinol-4-yl)-α-methylmalonate (3.0 g.) in ethanol (20 ml.) containing sodium hydroxide (3.0 g.) and water (3.0 ml.) was heated under reflux for 1 hour. The solution was then cooled and poured into water (200 ml.). The resultant solution was acidified to pH 3 by addition of concentrated hydrochloric acid to give α-(1-benzyl-1,2-dihydro-2-oxoquinol-4-yl)propionic acid 1.5 g., m.p. 179°-180° C.

Provenance & Evidence