Peracetic Acid → HCID 20375996, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 85 g of 3-(3-ethoxyphenoxy)pyridine in 500 ml of glacial acetic acid is treated with four 20 g portions of 40% peracetic acid in acetic acid. The mixture is stirred at 25° C. for 24 hours and is refluxed for 16 hours. The mixture is concentrated at reduced pressure, dissolved in 500 ml of dichloromethane and washed with excess 25% sodium hydroxide solution. The organic layer is dried, concentrated and distilled to yield 3-(3-ethoxyphenoxy)pyridine 1-oxide, bp 175°-177° C. at 0.4 mM.

Provenance & Evidence