Hydrazine → HCID 131711383, compound

HRID 1448865Notes

Reaction equation

HRID 1448865 reaction equation
[NH:1]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[C@H:2]([C:6]([N:8]1[CH2:20][CH2:19][CH2:18][C@H:9]1[C:10]([NH:12][CH2:13][C:14]([O:16]C)=O)=[O:11])=[O:7])[CH:3]([CH3:5])[CH3:4].[NH2:28][NH2:29]>CO>[NH:1]([C:21]([O:23][C:24]([CH3:27])([CH3:25])[CH3:26])=[O:22])[C@H:2]([C:6]([N:8]1[CH2:20][CH2:19][CH2:18][C@H:9]1[C:10]([NH:12][CH2:13][C:14]([NH:28][NH2:29])=[O:16])=[O:11])=[O:7])[CH:3]([CH3:5])[CH3:4]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 91979019HCID 91979019, compound

Product 1

HCID 131711383HCID 131711383, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of III (64.0 g, 166 mmol) in methanol (50 ml) was added 95% hydrazine (120 ml, 2.49 mol) and the mixture was stirred for 1 day at room temperature. The reaction mixture was evaporated and the residue, dissolved in chloroform, was washed with water and dried over sodium sulfate. The solution was evaporated and the residue was triturated with petroleum ether. A non-crystalline product obtained gave a single spot on TLC; yield 45.8 g (72%), Rf1 0.69.

Workup

  1. customThe reaction mixture was evaporated
  2. dissolutionthe residue, dissolved in chloroform
  3. washwas washed with water
  4. dry with materialdried over sodium sulfate
  5. customThe solution was evaporated
  6. customthe residue was triturated with petroleum ether
  7. customA non-crystalline product obtained
  8. customgave a single spot on TLC

Sources & evidence

ORD record
ord-7f7b30688d01429290ca61139f415665
Source dataset
uspto-grants-1980_02
Patent number
US04187852

Reaction notes

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