4-Nitrophenyl trifluoroacetate → HCID 131711387, compound

HRID 1448866Notes

Reaction equation

HRID 1448866 reaction equation
[NH:1]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[C@H:2]([C:6]([N:8]1[CH2:19][CH2:18][CH2:17][C@H:9]1[C:10]([NH:12][CH2:13][C:14]([OH:16])=[O:15])=[O:11])=[O:7])[CH:3]([CH3:5])[CH3:4].FC(F)(F)C(O[C:32]1[CH:37]=[CH:36][C:35]([N+:38]([O-:40])=[O:39])=[CH:34][CH:33]=1)=O>N1C=CC=CC=1>[NH:1]([C:20]([O:22][C:23]([CH3:24])([CH3:26])[CH3:25])=[O:21])[C@H:2]([C:6]([N:8]1[CH2:19][CH2:18][CH2:17][C@H:9]1[C:10]([NH:12][CH2:13][C:14]([O:16][C:32]1[CH:37]=[CH:36][C:35]([N+:38]([O-:40])=[O:39])=[CH:34][CH:33]=1)=[O:15])=[O:11])=[O:7])[CH:3]([CH3:5])[CH3:4]

Participants

4

Reactant 2

HCID 695694-Nitrophenyl trifluoroacetateHCID 131711388HCID 131711388, compound

Product 1

HCID 131711387HCID 131711387, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of XIV (4.4 g, 11.8 mmol) in pyridine (30 ml) was added p-nitrophenyl trifluoroacetate (3.22 g, 13.7 mmol). After stirring for 24 h at room temperature, the reaction mixture was treated in the same manner as described for the preparation of X. An oil obtained gave a single spot on TLC; yield 5.67 g (98%), Rf1 0.60.

Workup

  1. additionthe reaction mixture was treated in the same manner
  2. customas described for the preparation of X
  3. customAn oil obtained
  4. customgave a single spot on TLC

Sources & evidence

ORD record
ord-04f3d2d9b4944509a0fa7c8ddcc55265
Source dataset
uspto-grants-1980_02
Patent number
US04187852

Reaction notes

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