Sodium Hydroxide → HCID 13723667, compound

HRID 1448966Notes

Reaction equation

HRID 1448966 reaction equation
[Cl:1][C:2]1[C:16]([Cl:17])=[CH:15][C:5]2[O:6][CH:7]([C:10]([O:12]CC)=[O:11])[CH2:8][O:9][C:4]=2[CH:3]=1.[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[C:16]([Cl:17])=[CH:15][C:5]2[O:6][CH:7]([C:10]([OH:12])=[O:11])[CH2:8][O:9][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13723679HCID 13723679, compound

Product 1

HCID 13723667HCID 13723667, compoundYield 75.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrolysis of ethyl 6,7-dichloro-1,4-benzodioxan-2-carboxylate (5.0 g.) with sodium hydroxide (10%, 10.9 ml.) in ethanol (50 ml.) gave 6,7-dichloro-1,4-benzodioxan-2-carboxylic acid (3.4 g.) m.p. 155°-158° C. with a consistent NMR spectrum and identical Rf (TLC) with an authentic sample.

Sources & evidence

ORD record
ord-118b9528977d4d129e5ebd0a3bd4937f
Source dataset
uspto-grants-1980_02
Patent number
US04188390

Reaction notes

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