Ethanol → HCID 13723665, compound

Participants

Reaction Steps

Aqueous sodium hydroxide solution (1.2 g., in 5 ml. water) was added to a stirred solution of the product (7 g.) from (A) in ethanol (25 ml.) at 15° C. The reaction temperature was maintained below 25° C. for 1/2 hour then the mixture evaporated in vacuo, the residue triturated with water, acidified with concentrated hydrochloric acid and extracted with chloroform. The combined chloroform extracts were dried (MgSO4), evaporated in vacuo and the residue (1.46 g.) recrystallized from ethyl acetate/methanol to give 7-acetyl-1,4-benzodioxan-2-carboxylic acid, m.p. 167°-168° C.

Provenance & Evidence