HCID 13151841, compound → HCID 13151842, compound

Participants

Reaction Steps

A solution of 23 g of crude N-acetyl-4-(2-nitro-4-acetylphenyl)-piperidine in 250 ml of ethanol is hydrogenated with 4.5 g of palladium (5%) on barium carbonate (decomposed) until 3 equivalents of hydrogen have been absorbed. The catalyst is then filtered off, and the filtrate is concentrated in vacuo to dryness. The crude N-acetyl-4-(2-amino-4-acetyl-phenyl)-piperidine thus obtained is purified by way of the hydrochloride, m.p. 220°-222° (from ethanol).

Provenance & Evidence