HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 4-(p-Tolyl)piperidin-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1-Benzyl-4-(4-methylphenyl)piperidin-4-ol | HCID 198608 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(p-Tolyl)piperidin-4-ol | HCID 93912 | — |
Reaction Steps
30 g of N-benzyl-4-hydroxy-4-(4-methylphenyl)-piperidine in a mixture of equal parts of ethyl acetate and ethanol with palladium (5% on charcoal) is hydrogenated until one equivalent of hydrogen has been absorbed to give 4-hydroxy-4-(4-methylphenyl)-piperidine, m.p. 137°-138° (from ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04188396 |
| Source dataset | uspto-grants-1980_02 |
| ORD ID | ord-837cd625f1cc428287521841d5bcbe66 |
| Source note | uspto-grants-1980_02 |