HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxybenzaldehyde → 2-Acetoxymethyl-6-methyl-4-(2'-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxybenzaldehyde | HCID 8658 | — |
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Reactant | Ethyl 4-acetoxyacetoacetate | HCID 11480907 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Acetoxymethyl-6-methyl-4-(2'-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 70588764 | — |
Reaction Steps
A solution of 6.8 g of 2-methoxy-benzaldehyde, 9.4 g of γ-acetoxyacetoacetic acid ethyl ester and 6.5 g of β-aminocrotonic acid ethyl ester in 40 ccs of ethanol is heated to the boil overnight and then cooled. After filtering, light yellow crystals of melting point 84°-86° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04188395 |
| Source dataset | uspto-grants-1980_02 |
| ORD ID | ord-57d7ac2d71c548669d6d80ea04963018 |
| Source note | uspto-grants-1980_02 |